Influence of hydrophilic solid lipid nanoparticles on the absorption of drug in gastrointestinal tra

• 作 者: Hong Yuan Chun-Yan Chent Yong-Zhong Du Fu-Qiang Hu
• 机 构: College of Pharmaceutical Science,Zhejiang Uniersity,866 Yuhangtang Road,Hangzhou 310058,P.R.China
• 出 处: 2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2012年10期
• 关键词: Caco-2 cells HT-29 cells solid lipid nanoparticles otcadecylamine-fluorescein is

　　Objective:During the last decade years,Caco-2 cell monolayers have been used as an intestinal model to evaluate the effect of delivery systems on drug permeation via transcellular and paracellular transport.While it lacks goblet,mucus-secreting and M-cells.In order to better simulate the endosomatic environment in vitro,HT-29 subclones have been used in co-culture with Caco-2 cells to mimic the small intestinal epithelial layer.The aim of this study was to evaluate the transport properties of solid lipid nanoparticles (SLN) across Caco-2 and mucus-secreting Caco-2/HT29 co-culture cell monolayers.