Preparation of SLN Enriched Hydrogel for Topical Delivery of Astragaloside Ⅳ and Its Influence on Wo

• 作 者: Xi Chen Li-Hua Peng Ying-hui Shan Ni Li Jian-Qing Gao
• 机 构: Department of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,China
• 出 处: 2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2012年10期
• 关键词: solid lipid nanoparticle enriched hydrogel wound healing scar inhibition

　　Aim of the study:This study was to investigate the novel preparation of the solid lipid nanoparticle-enriched hydrogel (SLN-gel) for the topical delivery of astragaloside Ⅳ,as well as to study the influence of astragaloside Ⅳ based SLN-gel on wound healing and scar formation.Materials and methods:Solid lipid nanoparticle (SLN) was prepared by solvent evaporation method with glycerol tristearate and poloxamer 188 as lipid phase and surfactant,respectively.The particle size,polydispersity index (PDI),zeta potential (ZP),encapsulation efficiency (EE),drug release and morphological properties were characterized.