【摘 要】
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Discovery of catalytic antibodies (abzymes) was a revolutionary event that created new junctions between chemistry,biochemistry, immunology and pathology.Th
【机 构】
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Member of Russian Academy of Sciences, Lab ofbiocatalysis, IBCH RAS, Professor of the Moscow State U
【出 处】
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2005 WHTS'3rd Annual Congress of International Drug Disc
论文部分内容阅读
Discovery of catalytic antibodies (abzymes) was a revolutionary event that created new junctions between chemistry,biochemistry, immunology and pathology.The general concept of complementarity introduced in life sciences by Emil Fisher explains the driving force of various biological processes including genetic machinery, enzyme catalysis, ligandreceptor interaction, antibody-antigen recognition etc.Creation of abzymes as a new class ofbiocatalysts is based upon the intrinsic properties of immunoglobulin superfamily to produce complementary "molecular imprints" using the hypervariability of CDRs.These "catalytic imprints" could be made from the stable chemical analogs of transition state (TSA) of the enzyme reaction (Linus Pauling and Bill Jencks).This approach was successfully developed by Richard Lemer group (Scripps Research Institute, USA).The alternative way to create abzymes was proposed by author (Schuster et al., Science, 1992).It is generated on the basis of the immunological network hypothesis ofNiels Jerne and declares the formation of anti-idiotypic antibody repertoire razed against the active site of corresponding enzyme.
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