【摘 要】
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目的 Skin toxicity,especially hand-foot syndrome(HFS),is the most common sorafenibinduced adverse events in hepatocellular carcinoma(HCC)patients,leading to treatment interruption and failure.Mucocutane
【机 构】
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sun yat-sen university
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目的 Skin toxicity,especially hand-foot syndrome(HFS),is the most common sorafenibinduced adverse events in hepatocellular carcinoma(HCC)patients,leading to treatment interruption and failure.Mucocutaneous inflammation may causes HFS； therefore,we investigated whether celecoxib alleviate HFS,improve patientsquality of life and increase survival when administer in conjunction with active therapy.方法 Our study prospectively enrolled and assessed 116 advanced HCC patients receiving sorafenib as targeted therapy from July 2015 to July 2016.Sorafenib-related AEs were recorded,and survival was compared between the patients receiving sorafenib with or without celecoxib.结果 The results showed that compared to the control group,the sorafenib/celecoxib group had lower incidence rates of ≥grade 2 and grade 3 HFS(p＜0.001 and p=0.008,respectively),hair loss,rash and abdominal pain.The Kaplan-Meier analysis revealed a lower risk of ≥grade 2 HFS(HR 0.384,p=0.002)and a lower dose reduction/interruption rate(p＜0.001)in the sorafenib/celecoxib group than in the control group.Cox proportional hazards regression analysis demonstrated that the celecoxib was the only independent predictive factor of ≥grade 2 HFS(HR：0.414,p=0.004).Longer progression-free survival(PFS)was observed in the sorafenib/celecoxib group(p=0.040)than in the control group,although there was no prolongation of overall survival(p=0.122).结论 The administration of sorafenib and celecoxib alleviated sorafenib-related skin toxicity,including HFS,hair loss,rash and abdominal pain.Longer PFS was achieved in clinical practice,although there was no prolongation of overall survival(NCT02961998).
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