【摘 要】
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The abnormal bone marrow (BM)-derived mesenchymal stem cells (MSCs) maybe associated with the pathogenesis of systemic lupus erythematosus (SLE).Cell cycle arrest coupled with hyperactive mammalian ta
【机 构】
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Department of Rheumatology, Affiliated Hospital of Nantong University
论文部分内容阅读
The abnormal bone marrow (BM)-derived mesenchymal stem cells (MSCs) maybe associated with the pathogenesis of systemic lupus erythematosus (SLE).Cell cycle arrest coupled with hyperactive mammalian target of rapamycin (mTOR) leads to cellular senescence.Thus, we primarily confirmed that the mTOR signaling of SLE BM-MSCs was hyperactive in comparison with that of MSCs from normal subjects.
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