【摘 要】
：
The mammalian FOXO family of Forkhead transcription factors, consisting ofFOXOl, FOXO3a, and FOXO4, is a direct downstream target of the PI3K/Akt pathway.Po
【机 构】
：
Department of Obstetrics and Gynecology Saitama Medical University Hidaka, Saitama Japan
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
The mammalian FOXO family of Forkhead transcription factors, consisting ofFOXOl, FOXO3a, and FOXO4, is a direct downstream target of the PI3K/Akt pathway.Post-translational modification of FOXO proteins is an important mechanism that regulates the ability of different transcription factors to activate distinct gene sets, involved in cell cycle inhibition, apoptosis, defense against oxidative stress and DNA repair.FOXO-induced cell cycle arrest and apoptosis is critical as antiproliferative effect for tumors, whereas FOXO proteins play an important role in protection of cells against genotoxic and environmental stresses, such as FOXO-dependent resistance to oxidative stress for longevity.As FOXO possess diverse functions, which partly seemed opposing, the multiple mechanisms, including transcriptional activity and subcellular localization, are differentially regulated according to various typ es or intensities of cellular stress responses.
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