HIV-1 Tat Protein Induces Microglial Neurotoxic Activity Via Potassium Channel Kv1.3

来源 :2014第五届国际神经科技大会暨2014首届国际高科技针灸和中西医结合大会 | 被引量 : 0次 | 上传用户:wang8550cimc
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  Microglia plays a crucial role in the pathogenesis of HIV-l-associated neurocognitive disorders.Increasing evidence indicates the voltage-gated potassium (KV) channels are involved in the regulation of microglia function, prompting us to hypothesize KV channels may also be involved in microglia-mediated neurotoxic activity in HIV-l-infected brain.To test this hypothesis, we investigated the involvement of Kv channels in the response of microglia to HIV-1 Tat protein.
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