【摘 要】
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The global spread of methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem worldwide, and the situation is very severe in mainland China.In order to better understand the natio
【机 构】
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Department of Clinical Laboratory,Peking Union Medical College Hospital;Graduate School,Peking Union
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The global spread of methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem worldwide, and the situation is very severe in mainland China.In order to better understand the nationwide molecular epidemiology and resistant profile of hospital-associated MRSA (HA-MRSA) in China, the present laboratory-based multicenter surveillance study, organized 69 hospitals from 45 large cities 27 provinces were organized.A total of 1141 HA-MRSA isolates were collected during the half-year study period in 2011.All MRSA isolates were characterized by multilocus sequence tying (MLST), staphylococcal cassette chromosome mec (SCCmec) typing, spa typing, detection of thepvlgene, and antibiogram analysis.ST239-Ⅲ-t030, ST239-Ⅲ-t037 and ST5-Ⅱ-t002 were the most predominant HA-MRSA clones (overall prevalence 57.1%, 12.9% and 8.1%, respectively), whilst the prevalence of these major clones varied in different administrative regions.Of note, 6.6% of the HA-MRSA isolates was documented as ST59, which had typical community-associated MRSA (CA-MRSA) features including carried SCCmec IV/V/NT and the pv,lgene, and with narrow antimicrobial resistant profile comparing to other major clones.Moreover, amongst 36 sequence types (STs) identified in all, 15 were novel STs, accounting for 3.5% of total isolates.A novel ST named ST2590, which was evolved from clone ST5-Ⅱ-t002, was identified in 17 isolates from three hospitals in two large cities.To further monitoring trends of HA-MRSA prevalence, epidemic clone shift, new clone emerging and transmission of MRSA clones between community and healthcare settings, longitude nationwide MRSA surveillance is necessary.
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