Ghrelin/GHS-R1a signaling modulates synaptic transmission in primary cultured hippocampal neurons

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：zjundu1980

【摘要】

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【作者】

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Ge Song Nan Li Wei Sun Ming Yu Jie Yang Yu Zhou

【机构】

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Department of Physiology,Medical College of Qingdao University,Qingdao,Shandong,China

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

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　　The hippocampus plays important role in memory formation and spatial navigation.GHS-R1a,the only identified receptor for orexigenic peptide hormone ghrelin,was found to be highly expressed in hippocampal neurons.Our previous study showed that ghrelin micro-infusion into hippocampus impairs memory acquisition and GHS-R1a KO mice exhibits enhanced spatial memory,indicating the inhibition of ghrelin/GHS-R1a signaling on memory.

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Ghrelin/GHS-R1a signaling modulates synaptic transmission in primary cultured hippocampal neurons

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