【摘 要】
：
The rapid advancement of next-generation sequencing technology has generated a deluge of genomic data from domesticated dogs and their wild ancestor,grey wo
【机 构】
：
LaboratoryforConservationandUtilizationofBioresource&KeyLaboratoryforMicrobialResourcesoftheMinistry
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
The rapid advancement of next-generation sequencing technology has generated a deluge of genomic data from domesticated dogs and their wild ancestor,grey wolves,which have simultaneously broadened our understanding of domestication and diseases that are shared by humans and dogs.To address the scarcity of single nucleotide polymorphism (SNP) data provided by authorized databases and to make SNP data more easily/friendly usable and available,we propose DoGSD (http://dogsd.big.ac.cn),the first canidae-specific database which focuses on whole genome SNP data from domesticated dogs and grey wolves.The DoGSD is a web-based,open-access resource comprising ~19 million high-quality whole genome SNPs.In addition to the dbSNP data se (build 139),DoGSD incorporates a comprehensive collection of SNPs from two newly sequenced samples (1 wolf and 1 dog) and collected SNPs from three latest dog/wolf genetic studies (7 wolves and 68 dogs),which were taken together for analysis with the population genetic statistics,Fst.In addition,DoGSD integrates some closely related information including SNP annotation,summary lists of SNPs located in genes,synonymous and non-synonymous SNPs,sampling location and breed information.All these features make DoGSD a useful resource for indepth analysis in dog-/wolf-related studies.
其他文献
Cell fate determination and transformation is intimately related to chromatin interaction and 3D genome structure.Many 1D cancer or other developmental regu
Histone modifications are considered as fundamental epigenetic regulators that control many crucial cellular processes.However,whether these marks can be pa
Aging is a complex and universal phenomenon.In the last few decades,application of molecular genetics to the study of aging in model organisms has revealed
Sunflower Verticillium wilt (SVW) is a vascular disease caused by root infection of Verticillium dahlia.The sunflower (Helianthus annuus L.) leaves become y
We present a computational study of transcriptomic data of 6,000+ tissue samples of 14 cancer types,aiming to address the fundamental question: what may dri
Background: Single-cell RNA sequencing (scRNA-seq) is an emerging technology that enables high resolution detection of heterogeneities between cells.One imp
Background: Over the past decade,owing to rapid advances in the next-generation sequencing (NGS) technology,the cost of DNA sequencing has been reduced by o
Nematodes are considered major pests in agriculture.In recent years,overdose usage of chemical pesticides causes environmental damages and becomes a thread
The Encyclopedia of DNA Elements (ENCODE) Consortium has generated hundreds of high throughput genomic datasets with the goal of cataloging functional eleme
Gene fusions are often driving events in human cancers.The simultaneous availability of whole genome and RNA sequencing data for a large panel of cancer sam