【摘 要】
：
Histone modifications are considered as fundamental epigenetic regulators that control many crucial cellular processes.However,whether these marks can be pa
【机 构】
：
MOEKeyLaboratoryofBioinformatics,CenterforStemCellBiologyandRegenerativeMedicine,THU-PKUCenterforLif
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Histone modifications are considered as fundamental epigenetic regulators that control many crucial cellular processes.However,whether these marks can be passed on from gametes to the next generation in mammals is a long-standing question that remains unclear.By developing a highly sensitive approach,STAR ChIP-seq,we provided a panoramic view of the landscape of key histone modifications from developing gametes to postimplantation embryos.Interestingly,we found that upon fertilization,extensive reprogramming occurred on the paternal genome,as few H3K4me3 peaks were observed in zygotes before they reappeared after major zygotic genome activation.
其他文献
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease,characterized by chronic vascular wall inflammation,extracellular matrix degrad
Background: Lumican,a class Ⅱ small leucine-rich proteoglycans,have been designated key roles in extracellular matrix organization.Increasing number of evi
A set of new data types emerged from functional genomic assays,including ChIP-seq,DNase-seq,FAIRE-seq and others.The results are typically stored as genome-
Cell fate determination and transformation is intimately related to chromatin interaction and 3D genome structure.Many 1D cancer or other developmental regu