Peptide drugs born from computer

• 作 者: 张长胜 沈琦 来鲁华
• 机 构: 北京大学化学与分子工程学院,北京100871北京大学定量生物学中心,北京100871北京大学化学与分子工程学院,北京100871;北京大学定量生物学中心,北京100871
• 出 处: 2013年第四届全国“跨学科蛋白质研究”学术讨论会
• 发表日期: 2013年10期

　　Computationally designing novel proteins that can bind to a specific target protein is promising yer challenging, as binding and folding need to be considered at the same time.Regular secondary structures, especially a single helix, which is often involved in native protein-protein interactions, serve as an ideal folding motif for designing novel binders from scratch.