Diversification of the structural determinants of FGF-heparin interactions: implications for binding

来源 :3rd International Conference on Fibroblast Growth Factors (F | 被引量 : 0次 | 上传用户：yoyoyu2008

【摘要】

：

The functions of a large number (> 435) of extracellular regulatory proteins are controlled by their interactions with heparan sulfate (HS).In the case of fibroblast growth factors (FGFs), HS binding

【作者】

：

Ruoyan Xu

【机构】

：

Institute of Integrative Biology, University of Liverpool, UK

【出处】

：

3rd International Conference on Fibroblast Growth Factors (F

【发表日期】

：

2012年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The functions of a large number (> 435) of extracellular regulatory proteins are controlled by their interactions with heparan sulfate (HS).In the case of fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF receptor.However, the specificity of the interaction of FGFs with HS is still debated.

其他文献

Natural Orifice Hysterectomy and Native Tissue Repairs for Pelvic Organ Prolapse

For over a century, hysterectomy was performed by either the abdominal or the vaginal approach.Because of their long existence, abdominal hysterectomy (AH) and vaginal hysterectomy (VH) are often refe

会议

Computer-Aided Automatic Delivery System of High-Intensity Focused Ultrasound for Fetal Cardiac Inte

In recent years, several fetal cardiac malformations such as hypoplastic left heart syndrome have been increasingly treated before birth with gradually improved outcome, although the technique is stil

会议

My Experience in Burch Coloposuspension by Cherney's Incision for Stress Urinary Incontinence

Burch coloposuspension is gold standard in the management of stress urinary incontinence due to bladder neck hyper mobility.Preoperative evaluation of case selection for modified burch coloposuspensio

会议

Fatigue in Woman with Iron Deficiency without Anemia: Utopia or Reality?

Iron is one of the cornerstones of cellular function being key in hemoglobin and DNA synthesis and influencing enzymatic activity and especially mitochondrial function.The supposed association between

会议

Inadvertent Cystotomy at Laparoscopic Hysterectomy-Sydney West Advanced Pelvic Surgery (SWAPS) Unit

Inadvertent cystotomy is a recognised complication at hysterectomy.A retrospective observational study was conducted to analyse the rate of bladder injury at hysterectomy via laparoscopy at the Sydney

会议

Preferential Radio Frequency Ablation with Precision Placement of Needle-electrode Using Inertia Sta

Surgery for breast cancer has recently become less invasive.The first stage was reducing the amount of resected breast from mastectomy to partial resection.Second, was the shift from conventional axil

会议

Predisposing Factors for Fibroids and Outcome of Laparoscopic Myomectomy in Infertility

Exact cause of fibroids is not known & especially the impact on infertility is less evaluated.Ongoing research on fibroids shows high level of aromatase hence hyperestrogenemia.We also noticed that fi

会议

A Reconsideration of the Tubal Function-To Evaluate the Results Found Inside the Fallopian Tube When

Purpose: Although laparoscopy remains to be the gold standard for the evaluation of fallopian tubes, the process cannot be used to directly observe the inner cavity of the fallopian tube.Salpingoscopy

会议

Activated Protein C(APC)-a New Peptide for Ischemic Heart Disease

Background:Activated Protein C (APC) is a natural anticoagulant protein, with recently discovered anti-inflammatory and anti-apoptotic effects.We recently unveiled that APC can limit cardiac ischemia/

会议

Critical roles for FGFR1 in breast and pancreatic cancer

There is a growing body of evidence showing that FGFRs can be targeted to the nucleus.We investigate FGFR signalling in breast and pancreatic cancer cell line models, complementing these studies with

会议

Diversification of the structural determinants of FGF-heparin interactions: implications for binding

其他学术论文