C-reactive Protein Promotes Memory Deficits and β-Amyloid Plaque Formation in Early-stage AβPP/PS1 T

• 作 者: JiangpingXu;BingtianBi;YufangCheng;HuanbingLin;
• 机 构: Department of Pharmacology,School of Pharmaceutical Sciences,Southern Medical University
• 出 处: 全国老年性痴呆与相关疾病学术会议
• 发表日期: 2013年期

　　C-reactive protein (CRP) is associated with the risk of Alzheimers disease (AD) and progressive cognitive decline.However, the effects and related mechanisms of CRP in the early-stage pathogenesis of AD remain unknown.Behavioral and neurochemical tests were performed to investigate the association between CRP and cognitive function and amyloid-β (Aβ)deposition in early-stage AD.The object recognition test (ORT), the Morris water maze (MWM) test, and step-down passive avoidance (SDPA) were performed to evaluate learning and memory in 4-month-old Aβ precursor protein/presenilin 1 (AβPP/PS1) transgenic (Tg) mice after 60-day ventricular administration of CRP, a CRP inhibitor, and artificial cerebrospinal fluid (aCSF).