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Objective To optimize the preparation of Sirolimus-Nanostructured Lipid Carriers (SRL-NLC) dispersion,and study in vitro dissolution.Methods Apply Central composite design-response surface methodology for optimizing dispersion formulation,then to explore in vitro dissolution in 0.4% SDS(sodium lauryl sulfate) solution by normal phase filter bag method.Results The optimal dispersion has PS(Particle Size):82.54 nm,PI(Polydisperity Index):0.207,Zeta potential:-18.0 mv,DL (Drug-loading):1.829 %,and EE(Entrapment Efficiency):91.3 %;SRL-NLC dispersion has 120 h dissolution characterization in 0.4 % SDS solution by reverse phase dialysis bag method,and accumulated dissolution is 69.2 %.Conclusions in vitro dissolution curve shows SRL-NLC dispersion has a characterization of 69.2 % accumulated dissolution in 0.4 % SDS solution.