Targeting and Hyperthermia of doxorubicin by the Delivery of Single Walled Carbon Nanotubes to EC-10

• 作 者: HuijuanZhang;ZhenzhongZhang;
• 机 构: School of Pharmaceutical Sciences,Zhengzhou University,100 Kexue Avenue,Zhengzhou 450001,Henan,P.R.C
• 出 处: 2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2012年期

　　Aim:To introduce AS1411 (this aptamer targets nucleolin on the cell surface) to complex between ADM and SWNT to enhance targeted delivery of ADM,and to use 808 nm NIR laser for photothermal treatment to achieve the effect of targeting,controlled release and hyperthermiar.Methods:Water-soluble SWNTs were made by oxidizing and functionalizing with poloxamer 188.ADM-AS1411-SWNTs tertiary complex formation was formed according physical adsorption and electrostatic adsorption,lt was analyzed by TEM,infrared spectrophotometry,differential scanning calorimeter,particle size and potential analysis.