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The paper examines how geographic and technological proximity affect the spatial spillover of regional innovation according to a panel data from 31 Chinese provinces between 2000 and 2013.Using the method of ESDA,we find that there exists the spatial autocorrelation of innovation in Chinas province.To find the effect of geographic proximity and technological proximity on spatial spillovers of regional innovation,we establish geographic proximity matrix with spatial distance,and take collaborate patents from SIPO as technological proximity matrix.