Stim1 and Orai1 mediated store-operated calcium entry is critical for angiotensin Ⅱ-induced vascular

• 作 者: Rui-weiGuo[1]Li-xiaYang[1]Mao-quanLi[2]Xing-huaPan[3]BeiLiu[3]Yong-liDeng[3]
• 机 构: Department of Cardiology,Kunming General Hospital of Chengdu Military Area,Yunnan,China 650032
• 出 处: 第17届全军心血管内科学术会议
• 发表日期: 2011年期

　　Atherosclerosis is one of the most common diseases in developed and developing countries.The proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in intimal thickening of arterial wall commonly associated with atherosclerosis.Despite the fact that angiotensin Ⅱ(Ang Ⅱ) is a critical regulator of the proliferation, and migration of VSMC,but the effect of Ang Ⅱ on VSMCs proliferation has remained unclear.In this study, we demonstrated for the first time that Stim1 and Orai1 mediated store-operated calcium entry play a critical role in Ang Ⅱ-induced vascular smooth muscle ceils proliferation and Ang Ⅱ-accelerated neointimal growth after balloon injury of the rat carotid arteries.Knockdown of Stim1 and Orai1 suppresses AngⅡ-mediated Ca2+ entry and cells proliferation in synthetic VSMCs.