【摘 要】
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Liver X receptor is a member of the nuclear receptor superfamily of ligand-activated transcription factors, predominantly expressed in the cerebral cortex.We have previously demonstrated that LXRβ is
【机 构】
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Department of Physiology, Third Military Medical University, Chongqing 400038, China
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Liver X receptor is a member of the nuclear receptor superfamily of ligand-activated transcription factors, predominantly expressed in the cerebral cortex.We have previously demonstrated that LXRβ is essential for migration of later-born neurons during cerebral cortex development.The radial glial cells serve as scaffolds for new-born neurons migration during cerebral cortex development.Normally, the radial glial cells were transformationed into astrocytes around postnatal 14 days.Here, We found that the expression of LXRβ mRNA was higher than LXRα in the cerebral cortex of mice, of which the expression of LXRβ was gradually increased from E18.5 to P14.With specific markers for radial glia cells, we further found that loss of LXRβ induced the decreased level of BLBP in the cerebral cortex from E18.5 to P7 and increased level of GFAP from P2 to P14 compared to the WT littermates at the same age.TGF-β1 and Smad4 are believed to be related to the transformation of radial glial cells into astrocytes.The expression levels of TGF-β1 and Smad4 were increased significantly in the cerebral cortex of LXRβ knockout mice compared to the WT littermates from the E 18.5 to P7.Theres no difference in the expression levels of TGF-β1 and Smad4 between the LXRβ knockout mice and WT littermates from the P10 to P14.Taken together, our findings suggest that loss of LXRβ accelerates the transformation of radial glial cells into astrocytes through high levels of TGF-β1 and Smad4 in the cerebral cortex.
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