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Pre-eclampsia is a common and specific disease of pregnancy.And it is one of the main reasons causing pregnant women and neonatus to die.In this study, the normal and pre-eclamptic placental tissues are detected by micro-Raman spectroscopy with the spectrum resolution of 1 cm-1.We find that the protein structure of α-helix, β-pleated sheet and β-turn are overlying in pre-ectamptic placenta, which lead to a disorder of protein structure.The Raman peaks assign to tryptophan indole ring and phenylalanine in pre-eclamptic placental tissue are more higher than which in normal tissue.It suggests that the ordered structures of the main chain in protein molecules are reduced significantly, and the amino acid of side chains is damaged obviously.And a principal component analysis is used to classify the Raman spectra between normal and pre-eclamptic placental tissues.This study presents that Raman spectroscopy has a great potential on the mechanism research and diagnosis of placental lesions.