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  5. Cardiac transfection of AAV9-FrzA gene intervenes Wnt signal pathwy in ischemic heart failure mice

Cardiac transfection of AAV9-FrzA gene intervenes Wnt signal pathwy in ischemic heart failure mice

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：baihuiguo
【摘 要】
：
Background sFRP-1/FrzA, a secreted, frizzled-related protein and antagonist for the wnt/firzzled pathway, has certain treatment function in cardiovascular disease.Recombinant adeno-associated virus se
【作 者】
：
SHEN Xin MA Yi-tong YU Zi-xiang YANG Yi-ning LIU Fen CHEN Bang-dang CHEN You 
【机 构】
：
First Department of Coronary Heart Disease,First Affiliated Hospital of Xinjiang Medical University
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background sFRP-1/FrzA, a secreted, frizzled-related protein and antagonist for the wnt/firzzled pathway, has certain treatment function in cardiovascular disease.Recombinant adeno-associated virus serotype 9(rAAV9) has been proved to be the best carrier in gene therapy.We assessed the hypothesis that using rAAV9 to carry FrzA Gene transfection to ischemic heart failure mice to intervene Wnt signal pathway.
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