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  5. Attenuated Hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevent tumor occurrence thr

Attenuated Hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevent tumor occurrence thr

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：liongliong443
【摘 要】
：
Background: Hepatocellular carcinoma is the most common and deadliest form of primary liver tumors with limited treatment options.Nowadays, immunotherapy becomes a hot spot in liver cancer studies suc
【作 者】
：
Xin Wan Zhe Lin Ci Chen Yijia Song Runqiu Zhang Beicheng Sun Yun Chen 
【机 构】
：
Department of Immunology, Nanjing Medical University
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
【关键词】
：
Lmdd-MPFG Hepatocellular carcinoma Dendritic cells PRRs 
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Background: Hepatocellular carcinoma is the most common and deadliest form of primary liver tumors with limited treatment options.Nowadays, immunotherapy becomes a hot spot in liver cancer studies such as vaccine or immune cells related treatment.Lmdd-MPFG (LM) is a recombinant attenuated Listeria vaccine constructed in our previous study,which has potency to induce strong and specific antitumor cellular immunity to HCC.As the most powerful antigenpresenting cells, Dendritic cells (DCs) play an essential role in Lm infection.However, the Lm vaccine utilizes DCs to enhance antitumor immunity and the probable mechanisms have not been described.
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