【摘 要】
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Background: Diabetic arterial calcification has been indicated as a strong predictor of cardiovascular mortality.Vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells plays a p
【机 构】
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Center for translational medicine, Affiliated Hospital of Hainan Medical College, Haikou 570102, PR
【出 处】
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中国免疫学会第九届全国免疫学学术大会
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Background: Diabetic arterial calcification has been indicated as a strong predictor of cardiovascular mortality.Vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells plays a pivotal role during the vascular calcification.OPG (osteoprotegerin)/RANKL (receptor activator of NF-κB ligand)/RANK (receptor activator of NF-κB ligand) axis is r reported to be the linkage between bone mineralization and vasculature.This study aimed to investigate the effects of high glucose (HG) on the expression of OPG and RANKL in VSMCs.
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