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Ineffectiveness of long term gastric ulcer drug treatment or even resistance to it have promoted searches of anti-ulcer agents from natural sources.Berberis vulgaris (BV) was known for its anti-inflammatory, antioxidant and anticholinergic action, while the effect of its crude leaf extract on gastric ulcer was not considered before.The objective of the study was to evaluate the effect of crude BV leaf extract on ethanol-induced gastric mucosal ulceration in rats.