论文部分内容阅读
The establishment of human embryonic stem cell (hESC) and induced pluripotent stem cells (hiPSC) has greatly expanded our knowledge about the early development in human ontogeny.In the past decade, hESCs and hiPSCs have been proved excellent tools in characterization of molecular and cellular mechanisms controlling the normal and diseased differentiation of hematopoietic progenitors and mature, functional blood cells.Along with the advances in research, a clinical translation of hESC/hiPSC-derived hematopoietic cells as novel therapies has been foreseen in near future.In our laboratory, we recently established efficient blood cell-inducing systems by co-culture of hESC/hiPSCs with murine fetal stromal cells derived from aorta-gonad-mesonephros (AGM) region and fetal livers.