Deficient expression of miR-125a contributes to elevated RANTES by targeting KLF13 in lupus

• 作 者: ZHAO Xia TANG Yuan-Jia QU Bo CUI Hui-Juan LUO Xiao-Bin CHEN Shun-Le SHEN Nan
• 机 构: Renji Hospital,JiaoTong University School of Medicine, Shanghai 200001, China
• 出 处: 中国免疫学杂志第十二届学术研讨会
• 发表日期: 2009年1期

　　Objective:Inflammatory chemokines are fundamental regulators that direct immune cells to sites of in flammation and play a pivotal role in the tissue and organ inflammatory damage of lupus.Recent studies have implicated that microRNAs (miRNAs) contribute to the regulation of inflammatory process as posttranscriptional modulators.We re ported previously that aberrant expression of miR-146a negatively regulated type I IFN induction and contributed to the pathogenesis of SLE.In this study, we further investigate how aberrant expression of miRNAs contributes to the dysregula tion of inflammatory chemokines in SLE.Methods: Expression of the 156 miRNAs included in the Taqman microRNA As says was examined.