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Objective: To evaluate the mid-term clinical outcome of the Oxford Ⅲ unicompartmental knee arthroplasty(UKA)for the patients with the medial compartmentarthropathy of the knee jointonly.Methods:30 knees in 30 patients received the UKA with the mobile bearing Oxford Ⅲ prosthesis by a minimally invasive approach from January 2010 to June 2014.A retrospective study of the clinical outcomes was carried out.All patients were evaluated pre-and post-operatively using X-ray image,the Knee Society Score(KSS),the WOMAC index and VAS score.Results:The mean follow-up period was(47 ± 3.2)months.No patient had the complications of dislocation of the mobile bearing,infection,or thrombosis.No revision surgery was needed.The KSS Clinical Score and Function Score were improved from an average of(43.1 ± 2.1)and(49.1 ± 4.4)to(95.6 ± 4.3)and(95.1 ± 2.2)respectively.The mean WOMAC Score was(47.6 ± 3.2)preoperatively,and(10.4 ± 1.3)at the follow up.The VAS score dropped from(6.58 ± 1.12)preoperatively to(1.17 ± 0.29)postoperatively.Statistically significant differences were found pre-and post-operatively with those related index(P <0.05).Gonclusion: The mid-term clinical outcomes of the OxfordⅢ mobile-bearing UKA through a minimally invasive approach are satisfactory,and it is a goodalternative option for the patients with medial compartmentarthropathy of the knee only.