【摘 要】
：
Drug metabolism has become an integral part of drug discovery and development from the earliest stage, and this change may have been driven by the evolution
【机 构】
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School of Pharmaceutical Sciences, Shandong University, Jinan 250013, China
【出 处】
：
2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Drug metabolism has become an integral part of drug discovery and development from the earliest stage, and this change may have been driven by the evolution of better analytical technologies, in particular the MS technique.High resolution mass spectrometry (HRMS) instruments and HRMS-based data acquisition and data mining technologies have been developed recently to enhance HRMS capabilities in the comprehensive and rapid identification of drug metabolites.As a result, LC-HRMS has become a key analytical platform for drug metabolite identification, which includes metabolic soft spot analysis, reactive metabolite screening, and metabolite profiling in vivo.
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