Semi-mechanism-based pharmacokinetic/pharmacodynamic model for the combination use of dexamethasone

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户：moon818882003

【摘要】

：

　　Our study aimed at the investigation of in vivo anticancer effect of the combination use of dexamethasone (DEX) and gemcitabine (GM) as well as the developm

【作者】

：

YUANYin;LUWei;ZHOUTian-yan;

【机构】

：

School of Pharmaceutical science, Peking University, Beijing 100191, China

【出处】

：

2015年第一届药代动力学朝阳论坛

【发表日期】

：

2015年期

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　　Our study aimed at the investigation of in vivo anticancer effect of the combination use of dexamethasone (DEX) and gemcitabine (GM) as well as the development of pharmacokinetic/pharmacodynamic (PK/PD) models in MCF-7/Adrxenograft model.Further, simulations were conducted to optimize doses and administration schedules.The inhibitory effect of different doses and administration schedules were investigated in MCF-7/Adrxenograft model.Semi-mechanism-based PK/PD models were established based on the preclinical data to characterize the relationship between plasma concentration and the time-course of the drug response quantitatively.

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Semi-mechanism-based pharmacokinetic/pharmacodynamic model for the combination use of dexamethasone

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