Id1分子对TCR信号通路的影响及其机制

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：yecao126128

【摘要】

：

研究背景:Id1分子是一种抑制分化分子,它含有HLH结构域,可以和同样含有HLH结构域的E蛋白形成异源二聚体,抑制E蛋白的转录活性,对细胞的生存、分化产生影响.在T细胞相关的研究中,对于Id分子和E蛋白的研究主要集中于淋巴细胞的发育及免疫记忆细胞形成,而关于其发挥功能的一系列机制,目前还比较模糊.本研究主要探讨Id1分子影响TCR信号通路机制及其生物学意义.

【作者】

：

于森张毓

【机构】

：

北大医学部免疫系T细胞室

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

Id1分子 TCR受体信号转导

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Id1分子对TCR信号通路的影响及其机制

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