三结构域蛋白家族(Tripartite motif,Trim)的研究进展

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：xiaofyk

【摘要】

：

Trim家族存在于所有多细胞的动物体内,是包含了较多蛋白的一个相当大的家族,在人类体内已经发现70余种.Trim家族成员有典型的三个结构域,这三个结构域从N端到C端的依次是锌指结构域(RING finger)、1个或者2个B-box、1个卷曲螺旋(Coiled-coil)结构域.此外,该家族还有一个可变的C-末端.Ring结构域一般始于N端10-20个氨基酸残基.在功能上,锌指结构域结构不同底物或

【作者】

：

谢奇吴少华闫东梅朱迅

【机构】

：

吉林大学基础医学院河南省鹤壁职业技术学院

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

32例凶险型前置胎盘的临床分析

目的探讨凶险型前置胎盘的诊断、处理监测和预防方法方法回顾性分析我院三年来收治的32例凶险型前置胎盘的临床资料结果32例中凶险型前置胎盘26例,占81.25％,其中胎盘植入8例,部分型前置胎盘6例,占18.2％.32例均在我院行剖宫产,平均出血1200ML.手术采取胎儿娩出后,先结扎双侧子宫动脉,同时宫肌注射卡前列氨丁三醇后再处理胎盘,胎盘剥离面局部8字缝扎止血.酌情宫腔堵塞纱布等得以保留部分

会议

凶险型前置胎盘剖宫产胎盘植入

超声造影在高强度聚焦超声消融治疗子宫肌瘤及腺肌病即刻评价及补充治疗中的应用价值

目的探讨超声造影在高强度聚焦超声(HIFU)消融治疗子宫肌瘤及腺肌病的即刻疗效评价及补充治疗中的应用价值.方法 39例子宫肌瘤患者(44个病灶),18例子宫腺肌病患者(21个病灶),采用PRO2008超声聚焦子宫肌瘤治疗系统,在B超监控下对病灶进行治疗,治疗前、后即刻应用机载超声造影观察病灶血流灌注变化并及时引导补充治疗,计算消融率及补充治疗后消融率,对早期疗效做出判断.

会议

超声检查高强度聚焦超声子宫肌瘤子宫腺肌症补充治疗

Epigenetic influences on long-term phenotype of intergenerational rat offspring exposed to mild intr

Objective To establish the pregnant rat model of mild intrauterine hyperglycemia to observe the long-term effects of maternal mild hyperglycemia on the growing development and glucose and lipid metabo

会议

Bcl6 expression in B cell during germinal center formation

Background: Bcl6 is a critical transcription factor for germinal center B cell development and localization.However, the regulation of Bcl6 expression in germinal center B cell development remains to

会议

Bcl6germinal centerMD4 B cell

PTEN inhibited macrophage transformation from M1 to M2 through CCL2 and VEGF reduction and NHERF1/EB

目的:探讨肿瘤微环境中PTEN对CCL2、VEGF及NHEFR1/EBP50继而对巨噬细胞表型转化影响.方法:用小鼠乳腺癌4T1培养细胞上清(33.3％稀释比例)培养驯化RAW264.7细胞24至72小时模拟肿瘤微环境.将驯化后的RAW264.7细胞通过小干扰RNA技术沉默PTEN基因,或是通过加入PI3K抑制剂LY294002提高PTEN的表达建立两个PTEN不同表达水平的细胞模型.采用RT-P

会议

PTENCCL2VEGFNHERF1/EBP50Co-culture

Distinct immune responses induced by primary isolate HIV-1 envelope glycoprotein monomer and trimer

Improving the immunogenicity of HIV-1 envelope glycoproteins (Envs) is a challenge for vaccine development.Trimeric Envs may elicit specific binding antibodies (Abs) but less potent or broad neutraliz

会议

human immunodeficiency virus type 1envelopemonomertrimerimmune response

GM-CSF overrides FIt-3L signalling and re-conditions murine dendritic cell development in vivo--An i

Background: Two dendritic cell (DC) subsets are dependent on interferon regulatory factor 8 (IRF8): plasmacytoid DCs and conventional CD8+DCs.Granulocyte macrophage colony-stimulating factor (GM-CSF)

会议

Dendritic cell developmentGM-CSFCD8+DCs

Function of hepatitis C virus F protein expression in inducing transfected cell to transformation

Background: F protein expressed from the HCV core coding sequence.The recent discovery of this novel F protein certainly challenges whether core is responsible for the various activities attributed to

会议

Hepatitis C virus (HCV)F proteincellular transformation

Immune response induced by HCV F protein in peripheral blood mononuclear cells

Background Researchers reported a novel F protein, an alternative reading frame protein expressed from th HCV core coding sequence.It is found that F protein can induce humoral immunity in HCV infecte

会议

Hepatitis C virus (HCV)F proteinIL-10peripheral blood mononuclear cells (PBMC

Th1, Th2 and Th17 associated cytokines expression in hypopharyngeal carcinoma and clinical significa

Background.Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression.Th1 7 cells, a subset of IL-17-producing T cel

会议

hypopharyngeal carcinomaTh1Th2Th17cytokine

三结构域蛋白家族(Tripartite motif,Trim)的研究进展

其他学术论文