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Introduction Central hepatectomy is considered risky and technically demanding because the central liver is surrounded by many important vessels,and there are two liver resection planes,which makes the laparoscopic approach for this operative procedure even more difficult and rarely attempted.This article demonstrates the relevant technical maneuvers in the performance of totally laparoscopic central hepatectomy under the selective inflow occlusion.Case Description From June 2010 to November 2010,3 patients underwent totally laparoscopic central hepatectomy in our hospital.In the operation,we dissected the vessels to segment Ⅴ 、Ⅷ and segment Ⅳ first.After the resection of segments,the hepatoduodenal ligament was skelentonized and the lesion was removed with involved segments.Discussion The mean operation time was 331.7min (210-470min) and the mean blood loss was 1333.3ml (800-2000ml).The mean hospital stays were 17.0 days (10-22days) after operation.The bile duct to the left lateral lobe was transected by mistake in one case.Salvage end to end anastomosis of left lateral bile duct was performed with a 10F urethral catheter stent,through a 4.0cm incision on right upper quadrant.Laparoscopic central hepatectomy can be carried out in experienced hands of laparoscopic surgeons.