【摘 要】
：
BACKGROUND: Although growing body of evidences have identified a critical role for Receptor-interacting protein kinase 1 (RIP1) in mediating cell death signaling,its possible contribution to HCC progr
【机 构】
：
Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'
论文部分内容阅读
BACKGROUND: Although growing body of evidences have identified a critical role for Receptor-interacting protein kinase 1 (RIP1) in mediating cell death signaling,its possible contribution to HCC progression remains unclear.MATERIAL AND METHODS: RIP-1 expression was detected on tumor and adjacent liver tissues from 210 HCC patients by immunohistochemistry assay.The follow-up information was analyzed to figure out the role of RIP-1 on HCC prognosis.The in vitro experiments were carried out to identify the underlying mechanism.RESULTS: It was found that expression of RIP1 was significantly up-regulated in HCC tissues than adjacent liver tissues from 81.9% HCC patients (P < 0.001) by IHC staining.Over-expression of RIP1 was found positively associated with HBV infection,advanced TNM staging,portal vein invasion and intra-hepatic metastases.Kaplan-Meier curves analysis indicated that patients with higher RIP1 expression in HCC tissues suffered from unfavorable postsurgical survival.Higher RIP1 expression in HCC tissues was also confirmed to be a independent poor prognostic predictor.Knockdown of RIP1 resulted in suppression of cell viability and proliferation and induced cell apoptosis in MHCC97h cells.Nevertheless,enforced expression of RIP1 promoted cell viability and proliferation of Huh7 cells and inhibited cell apoptosis.Mechanistic studies revealed that RIP1 exerted its function on HCC progression via activating AKT/Bcl-2/BAX signaling.CONCLUSION: Our results provided the evidence of RIP1 over-expression in HCC,and RIP1 could be a novel predictive factor of unfavorable prognosis in HCC patients.Activation of AKT/Bcl-2/BAX signaling contributed to RIP1 promoting HCC progression.
其他文献
通过补充锂盐和两次烧成的方法对钛酸锂(LTO)废旧极片中活性物质LTO进行了回收与再利用.相比制备LTO极片时所用的负极活性材料LTO,回收的LTO材料具有更加优异的可逆容量和大倍率性能,在0.5C、1C、3C、5C、10C不同倍率下的放电容量依次为166mAh/g、162mAh/g、157mAh/g、148mAh/g、140mAh/g,在大倍率10C循环100次后,放电容量仅从141.5mAh/
随着近年新能源的发展,同时考虑到电网建设经济性因素多点随着近年新能源的发展,同时考虑到电网建设经济性因素多点T接线路正在被大量使用.接线路正在被大量使用.本文对多点T接线路的故障特征进行提取,并针对性地常规保护影响了评估而出接线路的故障特征进行提取,并针对性地常规保护影响了评估而出适用于多点T接线路的多端电流接线路的多端电流差动保护方案.本文提出的电流采用主从式拓扑结构,易于进行多点T接系统的扩展
传统核电的原子能利用,是在核电站厂区内实现核能——热能——电能转化,通过高压电网向用户远距离传输能源,实现人类核能大规模和平利用;但是传统核电站核能利用,主要通过核能——电能的转化利用,没有解决国民经济生产和生活中大量热能使用的需求;本文探讨通过大型商用反应堆远距离热能分布式发电供热设计方案,实现分布式区域内热电联产热能用户覆盖,替代一次化石能源,实现核能——热能大规模工业&民用的核能工程应用创新
Background: To evaluate the safety and feasibility of single incision laparoscopic cholecystectomy (SILC) using a novel instrument.Materials and methods: From September 2011 to June 2012,eligible pati
目的：探讨联合半肝切除的肝门部胆管癌的外科治疗及影响预后的因素.方法：回顾性分析2003年1月至2013年12月西安交通大学第一附属医院肝胆外科收治的63例联合半肝切除的肝门部胆管癌患者的临床资料.其中男35例,女28例；年龄25-77岁.分析肝门部胆管癌手术切除情况及影响预后的因素.计量资料以均数±标准差表示,采用t检验；计数资料采用卡方检验；生存情况分析采用Log-rank检验,单因素分析采用
HCC is the leading type of the malignant liver tumors with the unsatisfied prognosis.Liver resection has been considered as the predominant curative therapy,however,the post-surgical prognostic evalua
Background: Recently,it has been confirmed that lncRNA ( long non-coding RNA) CASC2 (Cancer susceptibility candidate 2) could participate in regulating the carcinogenesis and tumor progression to exer
AIM: Being overweight or obese is a leading risk factor for several cancers,however,the association between excess weight and the risk of gallbladder cancer (GBC) remains controversial.The objective o
Introduction: Laparoscopic procedures for pancreatic surgery have been significantly improved recently; however,only a limited number of successful laparoscopic or laparoscopy-assisted pancreaticoduod
Background: Increasing evidences demonstrate that miRNAs contribute to development and progression of hepatocellular carcinoma (HCC).Underexpression of miR-1296 is recently reported to promote growth