几丁质酶抑制剂的发现

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：olddai1

【摘要】

：

昆虫的几丁质酶家族group I主要负责蜕皮过程中表皮几丁质降解,被认为是农药设计的潜在靶标.通过分析亚洲玉米螟几丁质酶OfChtI催化域的晶体结构,发现其活性口袋底物结合裂缝处存在一系列芳香族氨基酸,提供其与底物结合的关键疏水作用,同时也是基于结构进行选择性抑制剂筛选的重要靶点.基于以上发现,通过对比底物几丁三糖化合物结构、电荷性质对商品化合物数据库进行虚拟筛选,获得了其抑制剂TP1,TP2.

【作者】

：

姜熙刘田杨青

【机构】

：

大连理工大学生命科学与技术学院

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

昆虫蜕皮几丁质几丁质酶抑制剂

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几丁质酶抑制剂的发现

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