Identification and functional inference for gastric tumor-associated long non-coding RNA

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：zhaoyun1111

【摘要】

：

　　Gastric cancer is one of the top leading causes of cancer death worldwide especially in China.In recent years,some lncRNAs are discovered to be dysregulated

【作者】

：

李瑛何叶梁艳春

【机构】

：

吉林大学计算机科学机科学与技术学院,符号计算与知识工程教育部重点实验室,长春,130012吉林大学珠海学院计算机科学与技术系,符号计算与知识工程教育部重点实验室珠海分实验室,珠海,519041吉林大学

【出处】

：

第七届全国生物信息学与系统生物学学术大会

【发表日期】

：

2016年10期

【关键词】

：

Bioinformatics Long non-coding RNA Cancer Tumor Differential express Co-expressi

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　　Gastric cancer is one of the top leading causes of cancer death worldwide especially in China.In recent years,some lncRNAs are discovered to be dysregulated in many cancers.The study on long non-coding RNAs (lncRNAs) relationship with cancers has attracted increasing attention.The molecular mechanism of gastric cancer remains largely unclear factors,especially for lncRNAs.Experiments are feasible to obtain related information,however,experimental identification of cancer-related lncRNAs usually possesses high time complexity and high cost.In this paper,a computational method is proposed to determine the relationship between lncRNA and gastric cancer by reusing the exon-based array of gastric cancer.One specific lncRNAs LINC00365 and its ta(r)get gene SOSTDC1 are found to be a candidate for a combined biomarker for gastric cancer.Further biological function and molecular mechanism of the gastric cancer related lncRNAs are inferred.

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Identification and functional inference for gastric tumor-associated long non-coding RNA

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