Influence of Intensive Insulin Therapy on Vascular Endothelial Growth Factor in Patients with Severe

• 作 者: Xiao-dongZHAO[1]Lian-yangZHANG[2]QinSU[2]Yu-hongQIN[1]Jun-xunMA[1]WeiDANG[1]ManWANG[1]XianZHANG[1]Hong-shengLIU[1]Jian-boZHANG[1]Yong-mingYao[1]
• 机 构: Emergency Department,the First Affiliated Hospital of PLA General Hospital,Beijing 100048,China
• 出 处: 2013北京协和急诊医学国际高峰论坛
• 发表日期: 2013年期

　　The influence of early-stage intensive insulin therapy on the plasma levels of vascular endothelial growth factor (VEGF) and the related parameters in patients with severe trauma and the clinical implication were investigated.Sixty-four cases of severe trauma (injury severity score ≥20) with stress hyperglycemia (blood glucose >9 mmol/L) were randomly divided into intensive insulin therapy group and conventional therapy group.ELISA Method,radioimmtmoassay and density gradient gradation one-step process were used to determine plasma VEGF,endothelin-1 (ET-1),and the number of circulating endothelial cells (CECs) at the day of 0,2,3,5 and 7 after admission.