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Lithium disilicate glass-ceramics is widely applied to the dental materials for the past years because of its moderate mechanical strength.The mechanical strength of Lithium disilicate glass ceramics was affected by the ratio of nucleation agent with glass modifiers and heat treatment that constrained bulk crystallization.By design of mixture experiment,the optimum ratio of glass composition was investigated for the crystallization of lithium disilicate with the fixed ratio of SiO2 and Li2O.