ndependent Oncogenic role of Phosphatase PRL-3 in FLT3-1TD-Negative Acute Myeloid Leukemia

• 作 者: Shuang Qun xiuzhen Tong haihe wang
• 机 构: SunYat-senUniversity
• 出 处: 中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
• 发表日期: 2014年8期
• 关键词: PRL-3 AML

INTRODUCTION: Internal tandem duplication of FMS-like tyrosine kinase (FLT3-ITD) is wellknown to be involved inacute myeloid leukemia (AML) progression, but FLT3-ITD-negative AML cases account for 70％ to 80％ of AML, and the mechanisms tmderlyingtheir pathology remain unclear.This study identifies protein tyrosine phophatase PRL-3 asa key mediator of FLT3-ITD-negative AML.