Nur77 (aka TR3 or NGFI-B) is an orphan nuclear receptor and plays important roles in carcinogenesis,inflammation,metabolism,and energy homeostasis.However,there
Identification of direct modulators of transcription factor proteinprotein interactions is a key challenge for ligand discovery that promises to significantly a
The secondary metabolites (or natural products),such as flavonoids,steroids,triterpenes,and antibiotics,are frequently post-modified with saccharides.These ubiq
The importance of cell surface oligosaccharides and glycosaminoglycans in signal transduction processes of biomedical significance is now well established.1 Des
Age is a major risk factor for morbidity and mortality for many infections caused by various pathogens.Many infectious diseases,such as influenza,tuberculos
Parkinsons disease(PD)is an age-dependent neurodegenerative disease that can be caused by genetic mutations in α-synuclein(α-syn)or duplication of wild-ty
Sexual dimorphism in brain size is common among primates,including humans,apes and some Old World monkeys.In these species,the brain size of males is genera
The Toll-like receptor 8(TLR8)is involved in the recognition of single-stranded RNA(ssRNA)form various viruses.Beside it,TLR8 also mediate the recognition o
Patients with systemic lupus erythematosus(SLE)are found to be accompanied with innate immunity dysregulation including abnormally macrophage activation.But