Electroresponsive mussel-inspired polydopamine films on bone implants for control of cell adhesion

• 作 者: GuoxinTan[1]KongyouOuyang[1]YanLiu[1]LeiZhou[2]ChengyunNing[3]
• 机 构: Institute of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 51
• 出 处: 2015 Shanghai Thin Film Conference(2015上海薄膜国际会议)
• 发表日期: 2015年期

　　The control over cell adhesion on bone implants is of crucial importance for the optimal osteointegration.In this study,we demonstrate the first time use of a mussel-inspired polymer,polydopamine(PDA),to achieve electroresponsive surface and studying cell-implant surface interactions in vitro in response to a weak potential [1].The ability of the described films to change its surface properties in response to an applied potential was investigated by observing the adhesion of MC3T3-E1 cells [2].The fluorescent micrographs in Figure 1a showed MC3T3-E1 cells did not spreading in the PDA coated titanium(Ti-PDA).Meanwhile,Ti-PDA-Oxidization(Figure 1 b),after a stimulus of constant voltage at +0.5V for 5min,induced a dense meshwork of peripheral actin filaments with more fibers appearing.Ti-PDA-Reduction(Figure 1c),at-0.1V for 5min,showed the actin filaments with only a few stress fibers appearing and extending further.These cells micrographs would promote osteogenic proliferation and differentiation on bone implant [3].