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At present, in many studies of drugs on the prevention of aging, extendedlifespan is associated with reducing the accumulation of free radicals such as quereetin,resveratrol, etc..Accumulation of free radicals in the organism mainly is double impactedby the rate of metabolism and antioxidant defense system.When there is an imbalance,the excess of ROS damages physiologically important cellular macromolecules like lipids,proteins as well as DNA and leads to the loss of cellular integrity and functionality.Variousmetabolic reactions in vivo are the main source of the production of endogenous free radicals,the low rate of metabolic generates less ROS, otherwise produce more ROS.