The effect of pH value on the conformational character of the core region (18-29) of the antimicrobi

• 作 者: 彭冉 赵立岭 曹赞霞 王吉华
• 机 构: 山东省功能大分子生物物理重点实验室,德州学院生物物理研究所,山东德州253023;山东师范大学物理与电子科学学院,济南250014山东省功能大分子生物物理重点实验室,德州学院生物物理研究所,山东德州2
• 出 处: 第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
• 发表日期: 2014年10期
• 关键词: antibacterial peptides molecular dynamics simulation LL-37 pH value the core reg

　　Background: LL-37 is an amphipathic α-helical antimicrobial peptide which is the unique member of Cathelicidin family discovered in human.LL-37, with broad-spectrum antimicrobial activity and difficulty to generate bacterial resistance, has become the preferred choice for the treatment of infections caused by multidrug-resistant bacterial strains.The residues segment 18-29 of LL-37 has been considered as the shortest peptide and the core region which have anti-microbial property The previous studies indicate that pH value has important effect on antibacterial activity and the antibacterial activity is consistent with the helical content.