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Up to 10% of the human genome is comprised by more than one million Alu repetitive elements, whose functions are not well understood yet.By systematically analyzing public genomic and epigenomic data sets, we show that Alu elements resemble enhancers.Alu elements are bound by two well-phased nucleosomes that contain histones bearing marks of active chromatin.They also show tissue-specific enrichment for the enhancer mark H3K4me1.