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目的:探讨糖尿病肾病(DN)发生的危险因素。方法:90例2型糖尿病患者根据尿蛋白排泄率分为三组:2型糖尿病正常蛋白尿组(DM组)、微量蛋白尿组(DN1组)、临床蛋白尿组(DN2组)。比较三组患者年龄、糖尿病病程、胆固醇、甘油三酯、糖化血红蛋白、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血清P-选择素、血清超敏C反应蛋白、尿单核细胞趋化蛋白1、尿蛋白排泄率等指标;并采用Logistic回归分析DN与各因素的相关性。结果:2型糖尿病病程、高密度脂蛋白胆固醇、P-选择素、超敏C反应蛋白、糖化血红蛋白、尿单核细胞趋化蛋白1等指标在各组间的差异均有统计学意义(P<0.05);
Objective: To investigate the risk factors of diabetic nephropathy (DN). Methods: 90 patients with type 2 diabetes were divided into three groups according to urinary protein excretion rate: type 2 diabetic normal proteinuria group (DM group), microalbuminuria group (DN1 group) and clinical proteinuria group (DN2 group). Age, duration of diabetes, cholesterol, triglycerides, HbA1c, high density lipoprotein cholesterol, low density lipoprotein cholesterol, serum P-selectin, serum C-reactive protein, urinary monocyte chemotactic protein 1, urinary protein excretion rate and other indicators; and the use of Logistic regression analysis of the correlation between DN and various factors. Results: There were significant differences in the duration of type 2 diabetes, high density lipoprotein cholesterol, P-selectin, Hs-CRP, HbA1c and urinary monocyte chemoattractant protein 1 in all groups (P <0.05);