ROS generated by cytochrome P450 mediated mitochondrial permeability transition induced by tetrandri

来源 :2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 | 被引量 : 0次 | 上传用户：xiaofeidong

【摘要】

：

【作者】

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GONG Li-kun QI Xin-ming CAI Yan REN Jin

【机构】

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Centre for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica,Shanghai 201203

【出处】

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2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛

【发表日期】

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2013年1期

【关键词】

：

tetrandrine mitochondrial permeability transition reactive oxygen species CYP450

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　　Tetrandrine is an alkaloid with a remarkable pharmacological profile that we previous reported causes hepatotoxicity through mitochondrial dysfunction.Here, we demonstrate that cytochrome P450 (CYP450) plays an important role in mitochondrial dysfunction induced by the administration of tetrandrine.The over production of reactive oxygen species (ROS) and the depletion of reduced glutathione were both induced by tetrandrine.

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ROS generated by cytochrome P450 mediated mitochondrial permeability transition induced by tetrandri

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