【摘 要】
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In this trial, nasopharyngeal cancer stem cells (CSCs)were separated and cultured to produce a vaccine;its safety and efficacy were prospectively evaluated in low-,medium-, and high-dose groups.Betwee
【机 构】
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Fuda Cancer Hospital, Jinan University School of Medicine, Guangzhou, China
【出 处】
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2016第五届国际(广州)癌症治疗论坛暨国际干细胞再生医学学会成立大会
论文部分内容阅读
In this trial, nasopharyngeal cancer stem cells (CSCs)were separated and cultured to produce a vaccine;its safety and efficacy were prospectively evaluated in low-,medium-, and high-dose groups.Between April and September 2014, we enrolled 90 patients who met the enrolment criteria, and assigned them to three groups (n=30).Throughout the trial, injection site reaction was the most common reaction (81%), and fever was least common (31%);however, there was no difference among the three groups.When the immune responses pre-and post-vaccination were compared, we found that the CSCspecific and-nonspecific response in the medium-and high-dose groups were both significantly enhanced.This study is the first clinical trial of a nasopharyngeal CSC vaccine and preliminarily proves its safety and efficacy.
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