【摘 要】
：
In this trial, lung cancer stem cells (CSCs) were separated and cultured to produce a vaccine;its safety and efficacy were prospectively evaluated in low-,medium-, and high-dose groups.Between Februar
【机 构】
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Fuda Cancer Hospital, Jinan University School of Medicine, Guangzhou, China
【出 处】
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2016第五届国际(广州)癌症治疗论坛暨国际干细胞再生医学学会成立大会
论文部分内容阅读
In this trial, lung cancer stem cells (CSCs) were separated and cultured to produce a vaccine;its safety and efficacy were prospectively evaluated in low-,medium-, and high-dose groups.Between February and September 2014, we enrolled 90 patients who met the enrollment criteria and assigned them to three groups (n=30).Throughout the trial, injection site reaction was the most common reaction (63%), and fever was least common (16%);however, there was no difference among the three groups.When the immune responses pre-and post-vaccination were compared, we found that the CSC-nonspecific and CSC-specific responses were both significantly enhanced in the medium-and high-dose groups.This study is the first clinical trial of a lung CSC vaccine and preliminarily proves its safety and efficacy.
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