【摘 要】
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Pathway enrichment analysis has been widely used to identify cancer risk pathways,and contributes to elucidating the mechanism of tumorigenesis.However,most of the existing approaches use the outdated
【出 处】
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第二届中国计算机学会生物信息学会议
论文部分内容阅读
Pathway enrichment analysis has been widely used to identify cancer risk pathways,and contributes to elucidating the mechanism of tumorigenesis.However,most of the existing approaches use the outdated pathway information and neglect the complex gene interactions in pathway.Here,we firstly reviewed the existing widely used pathway enrichment analysis approaches briefly,and then we proposed a novel Topology-based Pathway Enrichment Analysis(TPEA)method,which integrated topological properties and global upstream/downstream positions of genes in pathways.We compared TPEA with four widely used pathway enrichment analysis tools,including DAVID,GSEA,CePa and SPIA,through analyzing six gene expression profiles of three tumor types(colorectal cancer,thyroid cancer and endometrial cancer).
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