【摘 要】
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Comparing metabolic pathways provides a systematic way of understanding evolutionary and phylogenetic relationships in systems biology.Although a number of phylogenetic methods have been developed,few
【出 处】
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第二届中国计算机学会生物信息学会议
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Comparing metabolic pathways provides a systematic way of understanding evolutionary and phylogenetic relationships in systems biology.Although a number of phylogenetic methods have been developed,few efforts have been made to provide a unified phylogenetic framework which sufficiently reflects the metabolic features of organisms.Here we propose a phylogenetic framework which can characterize the metabolic features of organisms by aligning multiple metabolic pathways using functional module mapping.First,our method transforms the alignment of multiple metabolic pathways into constructing the union graph of pathways,and then the proposed method builds mappings between functional modules of pathways in union graph,and finally it infers phylogenetic relationships among organisms based on the module mappings.
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