【摘 要】
：
目的：根据艾滋病病毒(Human immunodeficiency virus,HIV)感染者的总淋巴细胞计数(Total lyophocyte count,TLC)预测CD+T淋巴细胞计数＜200个/μL的值进行系统评价.方法：检索中英文文献,并根据纳入标准对文献进行筛选.利用Meta-DiSc 1.4和Stata/SE 12.0软件,对纳入的研究结果按不同的TLC临界值分别进行合并灵敏度、特异
【机 构】
：
首都医科大学生物医学工程学院,北京100069 首都医科大学附属北京佑安医院,北京100069
【出 处】
：
首都医科大学生物医学工程学科学术年会
论文部分内容阅读
目的：根据艾滋病病毒(Human immunodeficiency virus,HIV)感染者的总淋巴细胞计数(Total lyophocyte count,TLC)预测CD+T淋巴细胞计数＜200个/μL的值进行系统评价.
方法：检索中英文文献,并根据纳入标准对文献进行筛选.利用Meta-DiSc 1.4和Stata/SE 12.0软件,对纳入的研究结果按不同的TLC临界值分别进行合并灵敏度、特异度、阳性预测值、阴性预测值的计算,绘制不同临界值的综合受试者工作特征曲线,计算曲线下面积并进行比较.
结果：共筛选文献12篇,按TLC临界值分别为1200个/μL、1300个/μL、1400个/μL及1500个/μL进行Meta分析.以TLC＜1200个/μL预测CD4＜200个/μL的合并灵敏度和特异度分别为0.62[95％可信区间(Confidence interval,CI):0.60～0.64]和0.81(95％ CI:0.80～0.82).不同TLC临界值下的综合受试者工作特征曲线下面积不相同,但差异无统计学意义.
结论：以TLC＜1200个/μL预测CD4＜200个/μL时准确性最高,此结果与世界卫生组织的建议一致.
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